团队带头人简介：

国果，女，医学博士，教授，博士生导师。1999.8参加工作，一直从事病原生物学教学及天然产物抗菌功能分子的研究。现任贵州医科大学转化医学研究中心主任。贵州省医学会热带病与寄生虫学分会常委。主要研究方向为微生物与抗微生物感染，聚焦多肽类抗微生物药物及微生物毒力、致病因子领域的研究。迄今主持了国家自然科学基金项目4项、国家教育部博士点专项基金项目1项、中国科学院“西部之光”项目及省部级科研项目6项，参与了国家科技部及国家自然科学基金等多个项目研究。主持省级教改项目1项，校级教改项目2项，参编教材13部。第一作者或通讯作者发表科研论文70多篇，其中20多篇被SCI收录；获省级科技进步三等奖1项（第2获奖人），省医学科技奖三等奖1项（第1获奖人），发明专利5项。指导学生参加“挑战杯”全国大学生课外学术科技作品竞赛、省级大学生创业项目等竞赛，获得国家级及省级二等奖、三等奖多项。获贵州省“千”层次创新型人才培养对象、校级骨干教师、优秀教师、优秀共产党员等称号。培养研究生22名，其中博士4名，硕士18名。

团队概况：

研究团队共有研究人员10名，包括教授2名，副教授4名，讲师3名，实验师1名。团队主要以临床病原微生物包括念珠菌、鲍曼不动杆菌等为研究对象，围绕此类病原微生物的耐药、毒力及与宿主的相互关系开展研究。近年来，由于微生物耐药问题日趋严峻，团队还开展肽类新型抗菌剂，主要针对真菌和细菌的抗菌机制进行研究。近5年来，研究团队主持国家自然科学基金4项，省级各类项目6项，累计项目经费达260余万元；累计发表论文37篇，其中SCI17篇，核心期刊20篇。授权发明专利1项。荣获省医学科技奖三等奖1项，指导学生获大学生创新创业项目在研2项，指导学生获得2020年、2021年国家生命科学竞赛三等奖1项目，省级奖4项。

代表性论文：

[1] Yang, L. B., G. Guo, et al. (2022). "TMT-based quantitative proteomic analysis of the effects of novel antimicrobial peptide AMP-17 against Candida albicans." J Proteomics 250 (104385): 1.

[2] Yang, L. B., G. Guo, et al. (2022). "In vitro antifungal activity of a novel antimicrobial peptide-AMP17 against planktonic cells and biofilms of Cryptococcus neoformans." Infect Drug Resist.

[3] Jiao, Z. L., G. Guo, et al. (2022). "Identification and function analysis of chitinase 2 gene in housefly, Musca domestica" Comp Biochem Phys B

[4] Peng, J., B. Mishra, et al. (2021). "Novel Cecropin-4 Derived Peptides against Methicillin-Resistant Staphylococcus aureus." Antibiotics 10(1).

[5] Zhang, C. R., M. Liu, et al. (2021). "Establishment of a Faba Bean Banker Plant System with Predator Orius strigicollis for the Control of Thrips Dendrothrips minowai on Tea Plants under Laboratory Conditions." Insects 12(5).

[6] Zhang, J., L. Yang, et al. (2021). "Large-Scale Screening of Antifungal Peptides Based on Quantitative Structure–Activity Relationship."

[7] Liu, W., Z. Wu, et al. (2020). "Antimicrobial Peptide Cec4 Eradicates the Bacteria of Clinical Carbapenem-Resistant Acinetobacter baumannii Biofilm." Front Microbiol 11(1532).

[8] Ma, H., X. Zhao, et al. (2020). "Antimicrobial Peptide AMP-17 Affects Candida albicans by Disrupting Its Cell Wall and Cell Membrane Integrity." Infect Drug Resist 13: 2509-2520.

[9] Wang, G., G. Guo, et al. (2020). "Screening and identification of MicroRNAs expressed in perirenal adipose tissue during rabbit growth." Lipids Health Dis 19(1): 020-01219.

[10] Wang, Y., J. Cheng, et al. (2020). "Identifying and Characterizing a Novel Peritrophic Matrix Protein (MdPM-17) Associated With Antibacterial Response From the Housefly, Musca domestica (Diptera: Muscidae)." J Insect Sci 20(6).

[11] Peng, J., H. Long, et al. (2019). "Antibacterial mechanism of peptide Cec4 against Acinetobacter baumannii." Infect Drug Resist 12: 2417-2428.

[12] Peng, J., Z. Wu, et al. (2019). "Antimicrobial functional divergence of the cecropin antibacterial peptide gene family in Musca domestica." Parasit Vectors 12(1): 019-3793.

[13] Yang, L. B., G. Guo, et al. (2019). "Antifungal Activity and Physicochemical Properties of a Novel Antimicrobial Protein AMP-17 from Musca domestica." Pol J Microbiol 68(3): 383-390.

[14] Jiao, Z., G. Wen, et al. (2018). "Induction of hemocyte apoptosis by Ovomermis sinensis: Implications for host immune suppression." J Invertebr Pathol 159: 41-48.

[15] Guo, G., R. Tao, et al. (2017). "Identification and characterization of a novel antimicrobial protein from the housefly Musca domestica." Biochem Biophys Res Commun 490(3): 746-752.

[16] Zhao, X., J. Xiu, et al. (2017). "Characterization and Expression Pattern Analysis of the T-Complex Protein-1 Zeta Subunit in Musca domestica L (Diptera)." J Insect Sci 17(4).

联系方式：

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